Piperacillin Kills Lyme Bacteria in Mice, Leaves Gut Microbiome Alone Already FDA-approved for pneumonia, the antibiotic shows promising results for Lyme disease

By Northwestern University

L yme disease, a disease transmitted when deer ticks feed on infected animals like deer and rodents, and then bite humans, impacts nearly half a million individuals in the U.S. annually.

Even in acute cases, Lyme can be devastating; but early treatment with antibiotics can prevent chronic symptoms like heart and neurological problems and arthritis from developing.

Scientists from Northwestern University have identified that piperacillin, an antibiotic in the same class as penicillin, effectively cured mice of Lyme disease at 100-times less than the effective dose of doxycycline, the current gold standard treatment.

Antibiotics wreak havoc on the microbiomeAt such a low dose, piperacillin also had the added benefit of “having virtually no impact on resident gut microbes,” according to the study, in the journal Science Translational Medicine.

Doxycycline and other generic antibiotics, on the other hand, wreak havoc on the microbiome, killing beneficial bacteria in the gut and causing troubling side effects even as it kills the Borrelia bacteria that causes Lyme.

In addition to its negative impact on the gut, doxycycline also fails to help between 10 and 20% of individuals who take it, and it is not approved for use in young children — who are at the highest risk of tick bites, and therefore, of developing Lyme……..Join or login below to continue reading.

You must be a LymeDisease.org member to access this content.

If you are already a member, log in below. Otherwise, become a member today to access the full content of this article and the full library of Lyme Times articles.
* Physician Directory Memberships do not have access to the Lyme Times.
patient-doctors-missed-lyme-disease-img1