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2014 Volume 26 Number 3

1

Volume 26

Number 3

2014

Photo courtesy of the National Institute of Health

Eva Sapi, micrograph of a Bb biofilm

Michele Lott, photo-illustration

PERSISTENCE

(cont.)

13 | Embers vs. the IDSA

Study contradicts IDSA

opinion on tests, treatment

and persistence

By Lorraine Johnson, JD, MBA

25 | Xenodiagnosis

Ticks detect persistent infection

in post-treatment patients

By Betty Maloney, MD

PATHOLOGY

28 | Borrelia Biofilms

A Complex slime renders

Bb

resistant to antibiotics

By Eva Sapi, PhD,

& David Luecke, MA

30 | Co-infections

Hundreds of unidentified

pathogens complicate treatment

By Lorraine Johnson, JD, MBA

31 | TBD Epidemiology

Biologist examines biodiversity

in California’s Lyme hotbeds

By Bob Lane, PhD

32 | Where are the Studies?

Science and politics conspire

to limit pathology-based research

By Tom Grier

33 | Lyme Neuropathology

Pathologist identifies

Bb

spirochete in Alzheimer’s

brain tissue

By Alan McDonald, MD

EDITORIAL

Informed advocates are

strong advocates

By Phyllis Mervine, EdM

RESEARCH

3 | Evidence-Based Medicine

Clinicians must weigh uncertain

science and patient values

By LorraineJohnson, JD, MBA

6 | NIH Trials

What conclusions can we draw

from four famous studies?

By Brian Fallon, MD, MPH, EdM

7 | Columbia TBD Research

Multidisciplinary team focuses on

persistent

Borrelia

infection

By Brian Fallon, MD, MPH, EdM

9 | Clinical Trials

CLD trial clarifies the benefits

of amoxicillin

By Dan Cameron, MD, MPH

36 | Patient-Powered Research

How patient involvement in

research design can improve care

By Lorraine Johnson, JD, MBA

PERSISTENCE

11 | Embers at a Glance

Monkey study confirms

post-treatment infection

By Lorraine Johnson, JD, MBA

12 | Evidence of Persistence

Worldwide studies confirm

persistent infection

By Raphael Striker, MD

& Lorraine Johnson, JD, MBA

14 | COVER STORY: ILADS Guidelines

Trustworthy treatment guidelines must reflect

available science, clinical judgment and patient values

By Dan Cameron, MD, MPH; Betty Maloney, MD;

& Lorraine Johnson, JD, MBA

5 | State of the Science

LLMD reviews what we know and don’t know

about tick-borne diseases drawn from his clinical

experience over the past 25 years

By Raphael Stricker, MD

24 | ILADS 2014 Conference

As the ILADS membership grows, increasing

numbers of practitioners benefit from a sea

of emerging knowledge

By Pamela Cocks, MPH, MLS

FEATURES

Wilhelm “Willy” Burgdorfer 1925-2014

The bacterium he discovered in 1982 that causes Lyme disease

is named in his honor:

Borrelia burgdorferi

.

Cover stories of

The Lyme Times

#57, Fall 2009 and #24, Summer 2012

feature evidence of persistence in Lyme disease.