2014 Volume 26 Number 3
1
Volume 26
Number 3
2014
Photo courtesy of the National Institute of Health
Eva Sapi, micrograph of a Bb biofilm
Michele Lott, photo-illustration
PERSISTENCE
(cont.)
13 | Embers vs. the IDSAStudy contradicts IDSA
opinion on tests, treatment
and persistence
By Lorraine Johnson, JD, MBA
25 | XenodiagnosisTicks detect persistent infection
in post-treatment patients
By Betty Maloney, MD
PATHOLOGY
28 | Borrelia BiofilmsA Complex slime renders
Bb
resistant to antibiotics
By Eva Sapi, PhD,
& David Luecke, MA
30 | Co-infectionsHundreds of unidentified
pathogens complicate treatment
By Lorraine Johnson, JD, MBA
31 | TBD EpidemiologyBiologist examines biodiversity
in California’s Lyme hotbeds
By Bob Lane, PhD
32 | Where are the Studies?Science and politics conspire
to limit pathology-based research
By Tom Grier
33 | Lyme NeuropathologyPathologist identifies
Bb
spirochete in Alzheimer’s
brain tissue
By Alan McDonald, MD
EDITORIALInformed advocates are
strong advocates
By Phyllis Mervine, EdM
RESEARCH
3 | Evidence-Based MedicineClinicians must weigh uncertain
science and patient values
By LorraineJohnson, JD, MBA
6 | NIH TrialsWhat conclusions can we draw
from four famous studies?
By Brian Fallon, MD, MPH, EdM
7 | Columbia TBD ResearchMultidisciplinary team focuses on
persistent
Borrelia
infection
By Brian Fallon, MD, MPH, EdM
9 | Clinical TrialsCLD trial clarifies the benefits
of amoxicillin
By Dan Cameron, MD, MPH
36 | Patient-Powered ResearchHow patient involvement in
research design can improve care
By Lorraine Johnson, JD, MBA
PERSISTENCE
11 | Embers at a GlanceMonkey study confirms
post-treatment infection
By Lorraine Johnson, JD, MBA
12 | Evidence of PersistenceWorldwide studies confirm
persistent infection
By Raphael Striker, MD
& Lorraine Johnson, JD, MBA
14 | COVER STORY: ILADS GuidelinesTrustworthy treatment guidelines must reflect
available science, clinical judgment and patient values
By Dan Cameron, MD, MPH; Betty Maloney, MD;
& Lorraine Johnson, JD, MBA
5 | State of the ScienceLLMD reviews what we know and don’t know
about tick-borne diseases drawn from his clinical
experience over the past 25 years
By Raphael Stricker, MD
24 | ILADS 2014 ConferenceAs the ILADS membership grows, increasing
numbers of practitioners benefit from a sea
of emerging knowledge
By Pamela Cocks, MPH, MLS
FEATURES
Wilhelm “Willy” Burgdorfer 1925-2014
The bacterium he discovered in 1982 that causes Lyme disease
is named in his honor:
Borrelia burgdorferi
.
Cover stories of
The Lyme Times
#57, Fall 2009 and #24, Summer 2012
feature evidence of persistence in Lyme disease.